Specification

Full name	MAP2K2 mouse monoclnal antibody
Alternative names	50 μl/100 μl
Reactivity	mouse monoclonal
Applications	WB
Host	Mouse
Clone type	mouse monoclonal
Target Background	The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, cognitive disability, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Swissprot No	P36507
Gene Accession
WB Predicted band size
WB Positive control	P114229-WB-1-P
WB Recommended dilution	44 kDa
IHC predicted cell location
IHC positive control
IHC Recommed dilution

Storage

Ascitic fluid with 0.05% sodium azide and 40% glycerol

P114229-WB-1-P