Bcakground

The human AGT is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.

Specifications

Synonyms	Angiotensinogen; SerpinA8AF; AGT; SERPINA8.
Accession #	P01019.
Source	Human embryonic kidney cell, HEK293-derived human Angitensinogen protein, Met 1-Ala 485.
Predicted Moleucular weight	49.8 kDa

Components and Storage

Formulation	Solution protein
	Dissolved in sterile PBS buer .
	This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening.
Storage and Stability	Avoid repeated freeze-thaw cycles.
	It is recommended that the protein be aliquoted for optimal storage.
	12 months from date of receipt, -20 to -70 as supplied.
Shipping	Shipping with dry ice

Quality

Purity	≥95%, determined by SDS-PAGE
Endotoxin Stability	＜0.01 EU per 1 µg of the protein by the LAL method.
Shipping	Testing in progress.

SDS-PAGE

Documents

Human AGT-flag