Specification

Full name	DIO2 rabbit polyclonal antibody
Alternative names	50 μl/100 μl
Reactivity	rabbit polyclonal
Applications	WB
Host	Rabbit
Clone type	rabbit polyclonal
Target Background	The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
Swissprot No	Q92813
Gene Accession	NP_000784
WB Predicted band size	31 kDa
WB Positive control
WB Recommended dilution	200-1000
IHC predicted cell location	nan
IHC positive control	nan
IHC Recommed dilution	nan

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

P110227-WB-1-P