Specification

Full name	TPMT rabbit monoclonal antibody
Alternative names	50 μl/100 μl
Reactivity	rabbit monoclonal
Applications	WB, IHC
Host	Rabbit
Clone type	rabbit monoclonal
Target Background	This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. [provided by RefSeq, Aug 2014]
Swissprot No	P51580
Gene Accession	7172
WB Predicted band size
WB Positive control	P291566-WB-1-P
WB Recommended dilution	28 kDa
IHC predicted cell location	Predicted cell location: Cytoplasm
IHC positive control	Positive control: Human cholangiocarcinoma
IHC Recommed dilution	Recommended dilution: 50-100

Storage

-20°C, 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA. Avoid repeated freeze-thaw cycles.

P291566-WB-1-P

Immunohistochemical analysis of paraffin-embedded Human cholangiocarcinoma tissue using P291566(TPMT Antibody) at dilution 1/50