Specification

Full name	STAT3 rabbit monoclonal antibody
Alternative names	50 μl/100 μl
Reactivity	rabbit monoclonal
Applications	WB, IHC, IF
Host	Rabbit
Clone type	rabbit monoclonal
Target Background	The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]
Swissprot No	P40763
Gene Accession	6774
WB Predicted band size
WB Positive control	P291479-WB-1-P
WB Recommended dilution	88 kDa
IHC predicted cell location	Predicted cell location: Nucleus
IHC positive control	Positive control: rat brain
IHC Recommed dilution	Recommended dilution: 50-100

Storage

-20°C, Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Avoid repeated freeze-thaw cycles.

WB PIC Description

P291479-WB-1-P

IHC PIC Description

Immunohistochemical analysis of paraffin-embedded rat brain tissue using P291479(STAT3 Antibody) at dilution 1/50

STAT3 rabbit monoclonal antibody