Description

Recombinant Human TGFB1 Protein (Transforming Growth Factor Beta 1) is a bioactive cytokine known for its crucial role in regulating cell proliferation, differentiation, and immune responses. TGFB1 is initially synthesized as a proprotein that undergoes proteolytic cleavage to yield the mature, active TGF-beta-1 and the latency-associated peptide (LAP). This recombinant form includes the functional core sequence of the mature protein and is ideal for use in in vitro studies requiring biologically active TGF-beta-1.

Protein general information

Protein name	transforming growth factor beta 1
Alternative protein names	Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide, LAP, Transforming growth factor beta-1, TGF-beta-1]
Gene name	TGFB1
Alternative gene name	TGFB
Accession	P01137
Organism	Homo sapiens (Human)
Full length	390 amino acids

Product Information

Product name	Recombinant Human TGFB1 Protein
Predicted molecular mass	55 kDa
Expression host	HEK293
Purification tag	MBP at N-terminus,6xHis at C-terminus
Form	Liquid
Buffer	0.15 M Phosphate buffered saline, pH 7.4
Shipping, storage and shelf life	Shipped on dry ice. Avoid repeated freeze-thaw cycles. Upon receipt, * 2 days when stored at 2 to 8 °C after thawing * Up to 12 months when aliquoted and stored at -20 to -80 °C

Core sequence

Core sequence start: Asp281
Core sequence stop: Ser390

......DTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS......

Note:The core sequence of the recombinant protein is shown above. The N and C termini have shortened by 0-10 amino acids. The exact sequence is proprietary information powered by SIEVE®.

Product data

SDS-PAGE

The purified product was run on 15% SDS-PAGE at reducing conditions. The gel was stained with Coomassie brilliant blue and destained.