{"product_id":"recombinant-human-osm-protein","title":"Recombinant Human OSM Protein","description":"\u003cstyle\u003e\n.biofargo-wrap{\n  font-family:'Segoe UI', Roboto, Helvetica, Arial, sans-serif;\n  color:#333;\n  line-height:1.7;\n  max-width:1000px;\n  margin:0 auto;\n}\n.biofargo-section{margin-top:32px;}\n.biofargo-h2{\n  color:#0056b3;\n  border-bottom:2px solid #0056b3;\n  padding-bottom:6px;\n  font-size:22px;\n  margin-bottom:16px;\n}\n.biofargo-desc{\n  background:#f7f9fc;\n  padding:18px;\n  border-radius:10px;\n}\n.biofargo-table-wrap{\n  overflow-x:auto;\n  -webkit-overflow-scrolling:touch;\n}\n.biofargo-table{\n  border-collapse:collapse;\n  width:100%;\n  min-width:860px;\n}\n.biofargo-table th{\n  background:#0056b3;\n  color:#fff;\n  padding:12px;\n  border:1px solid #e2e6ea;\n}\n.biofargo-table td{\n  border:1px solid #e2e6ea;\n  padding:12px;\n}\n.biofargo-table td:first-child{\n  font-weight:600;\n  background:#f6f8fa;\n}\n.biofargo-features{\n  list-style:none;\n  padding:0;\n  margin:0;\n}\n.biofargo-features li{\n  margin-bottom:16px;\n}\n.biofargo-features strong{\n  color:#0056b3;\n}\n.biofargo-grid{\n  display:grid;\n  grid-template-columns:repeat(2,1fr);\n  gap:16px;\n}\n.biofargo-card{\n  border:1px solid #e6e9ee;\n  border-radius:12px;\n  padding:16px;\n  background:#fff;\n}\n.biofargo-docs{\n  display:flex;\n  gap:12px;\n  flex-wrap:wrap;\n}\n.biofargo-btn{\n  padding:10px 16px;\n  border-radius:8px;\n  font-weight:600;\n  text-decoration:none;\n  font-size:14px;\n}\n.biofargo-btn-primary{\n  background:#0056b3;\n  color:#fff;\n}\n.biofargo-btn-secondary{\n  border:2px solid #0056b3;\n  color:#0056b3;\n}\n@media (max-width:640px){\n.biofargo-grid{\n  grid-template-columns:1fr;\n}\n}\n\u003c\/style\u003e\n\n\u003cdiv class=\"biofargo-wrap\"\u003e\n\n\u003cdiv class=\"biofargo-section\"\u003e\n\u003ch2 class=\"biofargo-h2\"\u003eDescription\u003c\/h2\u003e\n\u003cdiv class=\"biofargo-desc\"\u003e\n\u003cp\u003eOncostatin M (OSM) belongs to the interleukin-6 cytokine family.\u003c\/p\u003e\n\u003cp\u003eOSM is a glycoprotein secreted by activated monocytes, macrophages, T lymphocytes, and dendritic cells.\u003c\/p\u003e\n\u003cp\u003eOSM was first discovered as a factor that inhibits melanoma cell growth.\u003c\/p\u003e\n\u003cp\u003eOSM inhibits liver cancer cell proliferation by activating STAT3 signaling and upregulating oncogene c-Myc expression, while also accelerating cell senescence.\u003c\/p\u003e\n\u003cp\u003eIn addition, OSM participates in liver cell proliferation and tissue remodeling during liver regeneration.\u003c\/p\u003e\n\u003cp\u003eOSM can also inhibit the adipogenic differentiation of human bone marrow mesenchymal stem cells and stimulate their osteogenic differentiation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"biofargo-section\"\u003e\n\u003ch2 class=\"biofargo-h2\"\u003eSpecifications\u003c\/h2\u003e\n\u003cdiv class=\"biofargo-table-wrap\"\u003e\n\u003ctable class=\"biofargo-table\"\u003e\n\u003cthead\u003e\n\u003ctr\u003e\n\u003cth\u003eParameter\u003c\/th\u003e\n\u003cth\u003eSpecification\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003eExpression Host\u003c\/td\u003e\n\u003ctd\u003eHEK293 cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eSynonyms\u003c\/td\u003e\n\u003ctd\u003eOncostatin M; OSM; MGC20461\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eProtein Sequence\u003c\/td\u003e\n\u003ctd\u003eAmino acid sequence: Ala26–Arg221 of human OSM (UniProt ID: P13725)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMolecular Weight\u003c\/td\u003e\n\u003ctd\u003ePredicted molecular weight is 23.24 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePurity\u003c\/td\u003e\n\u003ctd\u003e\u0026gt;95%, analyzed by SDS-PAGE and HPLC\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eEndotoxin\u003c\/td\u003e\n\u003ctd\u003e\u0026lt;1 EU\/μg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003ePurification Method\u003c\/td\u003e\n\u003ctd\u003eChromatographic purification\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eAppearance\u003c\/td\u003e\n\u003ctd\u003eWhite lyophilized powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eActivity\u003c\/td\u003e\n\u003ctd\u003eRefer to COA for details\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"biofargo-section\"\u003e\n\u003ch2 class=\"biofargo-h2\"\u003eFeatures\u003c\/h2\u003e\n\u003cul class=\"biofargo-features\"\u003e\n\u003cli\u003e✔ \u003cstrong\u003eRecombinant Human Oncostatin M Protein\u003c\/strong\u003e\u003cbr\u003e\nHuman OSM corresponding to Ala26–Arg221 produced in HEK293 cells with a predicted molecular weight of 23.24 kDa.\u003c\/li\u003e\n\n\u003cli\u003e✔ \u003cstrong\u003eHigh-Purity Chromatographic Preparation\u003c\/strong\u003e\u003cbr\u003e\nPurity \u0026gt;95% confirmed by SDS-PAGE and HPLC following chromatographic purification.\u003c\/li\u003e\n\n\u003cli\u003e✔ \u003cstrong\u003eControlled Endotoxin Level\u003c\/strong\u003e\u003cbr\u003e\nEndotoxin content \u0026lt;1 EU\/μg, supporting reliable performance in sensitive in vitro cell culture experiments.\u003c\/li\u003e\n\n\u003cli\u003e✔ \u003cstrong\u003eDefined Lyophilized Protein Format\u003c\/strong\u003e\u003cbr\u003e\nSupplied as a white lyophilized powder with verified protein identity and consistent biological activity.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"biofargo-section\"\u003e\n\u003ch2 class=\"biofargo-h2\"\u003eApplications\u003c\/h2\u003e\n\u003cdiv class=\"biofargo-grid\"\u003e\n\n\u003cdiv class=\"biofargo-card\"\u003e\n\u003cstrong\u003eLiver Regeneration \u0026amp; Hepatocyte Biology\u003c\/strong\u003e\n\u003cp\u003eParticipates in hepatocyte proliferation and tissue remodeling processes during liver regeneration studies.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"biofargo-card\"\u003e\n\u003cstrong\u003eCancer Biology Research\u003c\/strong\u003e\n\u003cp\u003eUsed to investigate STAT3 signaling activation and c-Myc regulation involved in liver cancer cell proliferation and senescence mechanisms.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"biofargo-card\"\u003e\n\u003cstrong\u003eMesenchymal Stem Cell Differentiation\u003c\/strong\u003e\n\u003cp\u003eInhibits adipogenic differentiation of human bone marrow mesenchymal stem cells while promoting osteogenic differentiation.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"biofargo-card\"\u003e\n\u003cstrong\u003eStem Cell Culture Systems\u003c\/strong\u003e\n\u003cp\u003eApplicable for stem cell culture models including MSC and iPSC research environments.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"biofargo-section\"\u003e\n\u003ch2 class=\"biofargo-h2\"\u003eStorage\u003c\/h2\u003e\n\u003cp\u003eStore below -20°C\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"biofargo-section\"\u003e\n\u003ch2 class=\"biofargo-h2\"\u003eInstructions\u003c\/h2\u003e\n\u003cp\u003eCentrifuge before reopening the tube. Dissolve the lyophilized protein in distilled water. It is recommended to reconstitute the concentration to greater than 100 μg \/mL.\u003c\/p\u003e\n\u003cp\u003eAfter reconstitution, the protein can be stored at -80℃ for 3-6 months and at 2-8℃ for 2-7 days. For optimal storage, aliquot the protein and minimize freeze-thaw cycles.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"biofargo-section\"\u003e\n\u003ch2 class=\"biofargo-h2\"\u003ePrecautions\u003c\/h2\u003e\n\u003cp\u003eThis product is only suitable for in vitro cell culture and cannot be used directly in clinical treatment.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\u003cdiv class=\"biofargo-section\"\u003e\n\u003ch2 class=\"biofargo-h2\"\u003eDocuments\u003c\/h2\u003e\n\u003cdiv class=\"biofargo-docs\"\u003e\n\u003ca class=\"biofargo-btn biofargo-btn-primary\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0521\/5312\/2997\/files\/Recombinant_Human_OSM_Protein_SDS_1.pdf?v=1762240368\"\u003eSDS\u003c\/a\u003e\n\u003ca class=\"biofargo-btn biofargo-btn-secondary\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0521\/5312\/2997\/files\/Recombinant_Human_OSM_Protein_User_Manual.pdf?v=1762243701\"\u003eUser Manual\u003c\/a\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\n\u003c\/div\u003e","brand":"T\u0026L","offers":[{"title":"50μg","offer_id":51380901085365,"sku":"TL-772-0050","price":230.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0521\/5312\/2997\/files\/IMG-TL-722-0050.png?v=1772773640","url":"https:\/\/biofargo.com\/products\/recombinant-human-osm-protein","provider":"Biofargo","version":"1.0","type":"link"}