{"product_id":"recombinant-human-nrg1-β1","title":"Recombinant Human NRG1-β1","description":"\u003cstyle\u003e.biofargo-table-wrapper {overflow-x: auto;margin: 20px 0;-webkit-overflow-scrolling: touch;}.biofargo-spec-table {width: 100%;border-collapse: collapse;border: 1px solid #dee2e6;min-width: 600px;background: #fff;}.biofargo-spec-table th,.biofargo-spec-table td {border: 1px solid #dee2e6;padding: 12px;vertical-align: middle;white-space: normal;word-break: break-word;}@media (max-width: 600px) {.biofargo-table-wrapper {border: 1px solid #eee;border-radius: 8px;padding: 6px;background: #fff;}.biofargo-spec-table {min-width: 720px;}}\u003c\/style\u003e\n\u003cdiv style=\"font-family: 'Segoe UI', Roboto, Helvetica, Arial, sans-serif; color: #333; line-height: 1.6; max-width: 1000px; margin: 0 auto; border: 1px solid #e1e8ed; padding: 30px; border-radius: 10px; background-color: #ffffff;\"\u003e\n\u003ch2 style=\"color: #0056b3; border-bottom: 2px solid #0056b3; padding-bottom: 8px; margin-top: 0; font-size: 22px;\"\u003eDescription\u003c\/h2\u003e\n\u003cdiv style=\"background-color: #fcfcfc; padding: 15px; border-radius: 6px; border: 1px solid #f0f0f0;\"\u003e\n\u003cp\u003eRecombinant Human Neuregulin-1 beta 1 (NRG1-β1) is a member of the neuregulin family of growth factors that plays a critical role in cell proliferation, differentiation, and survival. It functions by binding to ErbB receptor tyrosine kinases (ErbB3 and ErbB4), activating downstream signaling pathways such as PI3K\/AKT and MAPK. NRG1-β1 is widely involved in cancer biology, neural development, and cell communication.\u003c\/p\u003e\n\u003cp\u003eThis recombinant protein is expressed in E. coli and corresponds to the functional region (S177–E241) of human NRG1-β1, retaining its biological activity. With high purity (≥95%) and validated bioactivity (ED50: 1–8 ng\/mL in MCF-7 cell proliferation assay), this product is suitable for a wide range of applications in oncology and cell signaling research. The protein is supplied in a tag-free, lyophilized form for convenient storage and reconstitution.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch2 style=\"color: #0056b3; border-bottom: 2px solid #0056b3; padding-bottom: 8px; margin-top: 30px; font-size: 22px;\"\u003eSpecifications\u003c\/h2\u003e\n\u003cdiv class=\"biofargo-table-wrapper\"\u003e\n\u003ctable class=\"biofargo-spec-table\"\u003e\n\u003cthead\u003e\n\u003ctr style=\"background-color: #0056b3; color: white;\"\u003e\n\u003cth style=\"padding: 12px; text-align: left;\" colspan=\"2\"\u003eProduct Details\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eCat. No.\u003c\/td\u003e\n\u003ctd\u003eY01621H\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003ePurity\u003c\/td\u003e\n\u003ctd\u003e≥95%, by SDS-PAGE (under reducing (R) \u0026amp; Non-reducing conditions, visualized by Coomassie staining).\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eEndotoxin\u003c\/td\u003e\n\u003ctd\u003e≤10 EU\/mg by the LAL method.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eBioactivity\u003c\/td\u003e\n\u003ctd\u003eMeasured in a cell proliferation assay using MCF-7 breast cancer cell line.The ED50 for this effect is 1-8 ng\/mL.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eAccession\u003c\/td\u003e\n\u003ctd\u003eNP_039250\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eAlternative Names\u003c\/td\u003e\n\u003ctd\u003e\/\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eSpecies\u003c\/td\u003e\n\u003ctd\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eExpression System\u003c\/td\u003e\n\u003ctd\u003eE. coli\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eMol. Weight\u003c\/td\u003e\n\u003ctd\u003e7.5 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eExpression Region\u003c\/td\u003e\n\u003ctd\u003eS177-E241\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eTag Info\u003c\/td\u003e\n\u003ctd\u003eTag free\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eFormulation\u003c\/td\u003e\n\u003ctd\u003eLyophilized\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eBuffer\u003c\/td\u003e\n\u003ctd\u003eLyophilized from a 0.22 μm-filtered solution containing 10 mM PB, 5% Trehalose and 0.01% Tween 80, pH7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eSize\u003c\/td\u003e\n\u003ctd\u003e10μg\/50μg\/1mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eLead Time\u003c\/td\u003e\n\u003ctd\u003eProducts are in stock,but custom products may require further consultation.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eReconstitution\u003c\/td\u003e\n\u003ctd\u003eIt is recommended to redissolve in sterile deionized water.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eShipping\u003c\/td\u003e\n\u003ctd\u003eThe product is shipped with blue ice.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd style=\"font-weight: bold; background-color: #f8f9fa;\" width=\"26%\"\u003eStorage \u0026amp; Stability\u003c\/td\u003e\n\u003ctd\u003e36 months at -20°C to -80°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003ch2 style=\"color: #0056b3; border-bottom: 2px solid #0056b3; padding-bottom: 8px; margin-top: 30px; font-size: 22px;\"\u003eFeatures\u003c\/h2\u003e\n\u003cul style=\"list-style-type: none; padding: 0;\"\u003e\n\u003cli style=\"margin-bottom: 15px; padding-left: 30px; position: relative;\"\u003e\n\u003cspan style=\"position: absolute; left: 0; color: #0056b3; font-weight: bold;\"\u003e✔\u003c\/span\u003e \u003cstrong\u003eHigh Purity:\u003c\/strong\u003e This product undergoes stringent purification processes, achieving a purity level of ≥95%, ensuring reliable and reproducible experimental results.\u003c\/li\u003e\n\u003cli style=\"margin-bottom: 15px; padding-left: 30px; position: relative;\"\u003e\n\u003cspan style=\"position: absolute; left: 0; color: #0056b3; font-weight: bold;\"\u003e✔\u003c\/span\u003e \u003cstrong\u003eHigh Biological Activity:\u003c\/strong\u003e Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.\u003c\/li\u003e\n\u003cli style=\"margin-bottom: 15px; padding-left: 30px; position: relative;\"\u003e\n\u003cspan style=\"position: absolute; left: 0; color: #0056b3; font-weight: bold;\"\u003e✔\u003c\/span\u003e \u003cstrong\u003eOptimized Expression System:\u003c\/strong\u003e Expressed in E. coli, enabling efficient production and suitability for routine laboratory applications.\u003c\/li\u003e\n\u003cli style=\"margin-bottom: 15px; padding-left: 30px; position: relative;\"\u003e\n\u003cspan style=\"position: absolute; left: 0; color: #0056b3; font-weight: bold;\"\u003e✔\u003c\/span\u003e \u003cstrong\u003eConvenient and Reliable:\u003c\/strong\u003e Supplied in a tag-free, lyophilized form for easy reconstitution, stable storage, and compatibility with various experimental workflows.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"color: #0056b3; border-bottom: 2px solid #0056b3; padding-bottom: 8px; margin-top: 30px; font-size: 22px;\"\u003eApplications\u003c\/h2\u003e\n\u003cdiv style=\"display: grid; grid-template-columns: 1fr 1fr; gap: 20px;\"\u003e\n\u003cdiv style=\"border: 1px solid #e1e8ed; padding: 15px; border-radius: 8px;\"\u003e\n\u003ch4 style=\"margin-top: 0; color: #333;\"\u003eNeuroscience\u003c\/h4\u003e\n\u003cp style=\"font-size: 14px; margin-bottom: 0;\"\u003eInvolved in neural development and cell communication, supporting research on nervous system function and disorders.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e1e8ed; padding: 15px; border-radius: 8px;\"\u003e\n\u003ch4 style=\"margin-top: 0; color: #333;\"\u003eCancer Research\u003c\/h4\u003e\n\u003cp style=\"font-size: 14px; margin-bottom: 0;\"\u003eWidely used in studies of tumor progression and signaling, especially in breast cancer models such as MCF-7 cells.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv style=\"border: 1px solid #e1e8ed; padding: 15px; border-radius: 8px;\"\u003e\n\u003ch4 style=\"margin-top: 0; color: #333;\"\u003eCell Biology\u003c\/h4\u003e\n\u003cp style=\"font-size: 14px; margin-bottom: 0;\"\u003eRegulates cell proliferation, differentiation, and survival via ErbB receptor-mediated signaling pathways.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003ch2 style=\"color: #0056b3; border-bottom: 2px solid #0056b3; padding-bottom: 8px; margin-top: 30px; font-size: 22px;\"\u003eData Figures\u003c\/h2\u003e\n\u003cdiv style=\"text-align: center; margin-top: 20px; border: 1px solid #eee; padding: 15px; border-radius: 8px;\"\u003e\n\u003cimg style=\"max-width: 100%; height: auto;\" alt=\"Measured in a cell inhibitionn assay using TF-1 cells at IL4 presence. The ED50 for this effect is ≤0.2 ng\/mL. The bioactivity of Y07901 was higher than other competing products.\" src=\"https:\/\/files.biofargo.com\/eastmabbio\/product-detail-images\/Y07901_1.jpg\"\u003e\n\u003cp style=\"font-size: 13px; color: #888; margin-top: 10px;\"\u003eFigure 1: Measured in a cell inhibitionn assay using TF-1 cells at IL4 presence. The ED50 for this effect is ≤0.2 ng\/mL. The bioactivity of Y07901 was higher than other competing products.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch2 style=\"color: #0056b3; border-bottom: 2px solid #0056b3; padding-bottom: 8px; margin-top: 30px; font-size: 22px;\"\u003eInstructions for Use\u003c\/h2\u003e\n\u003cul style=\"padding-left: 20px;\"\u003e\n\u003cli style=\"margin-bottom: 8px;\"\u003eDissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.\u003c\/li\u003e\n\u003cli style=\"margin-bottom: 8px;\"\u003ePrepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.\u003c\/li\u003e\n\u003cli style=\"margin-bottom: 8px;\"\u003eDo not mix with other similar products to avoid cross-reactivity and potential interference.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 style=\"color: #0056b3; border-bottom: 2px solid #0056b3; padding-bottom: 8px; margin-top: 30px; font-size: 22px;\"\u003eCautions\u003c\/h2\u003e\n\u003cdiv style=\"background-color: #fff5f5;  padding: 15px; color: #852d2d; font-size: 14px;\"\u003e\n\u003cp style=\"margin: 0 0 8px 0;\"\u003e\u003cstrong\u003e• Research Use Only:\u003c\/strong\u003e This product is not suitable for clinical diagnostics or therapeutic applications.\u003c\/p\u003e\n\u003cp style=\"margin: 0 0 8px 0;\"\u003e\u003cstrong\u003e• Preservation:\u003c\/strong\u003e Handle according to instructions to preserve its activity and stability.\u003c\/p\u003e\n\u003cp style=\"margin: 0;\"\u003e\u003cstrong\u003e• Support:\u003c\/strong\u003e Contact our technical support team if you encounter any issues or questions.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003ch2 style=\"color: #0056b3; border-bottom: 2px solid #0056b3; padding-bottom: 8px; margin-top: 30px; font-size: 22px;\"\u003eDocuments\u003c\/h2\u003e\n\u003cdiv style=\"display: flex; gap: 15px; margin-top: 10px; flex-wrap: wrap;\"\u003e\u003ca style=\"display: inline-block; padding: 10px 20px; border: 2px solid #0056b3; color: #0056b3; text-decoration: none; border-radius: 5px; font-weight: bold; font-size: 14px;\" href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0521\/5312\/2997\/files\/c4b7b7957143980f114f244e91a12dfa.pdf?v=1775009374\" target=\"_blank\"\u003e📄 Download COA\u003c\/a\u003e\u003c\/div\u003e\n\u003c\/div\u003e","brand":"EastMabBio","offers":[{"title":"10ug","offer_id":52404303888565,"sku":"Y01621H-10ug","price":79.0,"currency_code":"USD","in_stock":true},{"title":"50ug","offer_id":52404303921333,"sku":"Y01621H-50ug","price":276.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":52404303954101,"sku":"Y01621H-1mg","price":1740.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0521\/5312\/2997\/files\/1729670532493493_1cf5c13c-6372-4ff6-8eeb-8924a88831ab.jpg?v=1775009245","url":"https:\/\/biofargo.com\/products\/recombinant-human-nrg1-%ce%b21","provider":"Biofargo","version":"1.0","type":"link"}