Description

FGF-10 (Fibroblast Growth Factor 10), a member of the FGF family, is a secreted protein that is highly homologous to FGF-7 (KGF) and functions by binding to the FGFR2b receptor. It is primarily involved in epithelial-mesenchymal interactions, regulating embryonic development, tissue repair, and organ formation (such as in the lungs, skin, and prostate). FGF-10 promotes the proliferation of epithelial cells (e.g., keratinocytes, alveolar epithelial cells, and mammary epithelial cells) and certain mesenchymal stem cells (MSCs). In synergy with the Wnt signaling pathway, it is used for the long-term culture of organoids, such as those derived from the intestine and lungs.

Specifications

Product Details
Cat. No.	Y01121H
Purity	≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining).
Endotoxin	≤10 EU/mg by the LAL method.
Bioactivity	Measured by its ability to induce IL-11 secretion by Saos-2 human osteosarcoma cells. The ED50 for this effect is ≤1 ug/mL.
Accssion	O15520
Alternative Names	Fibroblast growth factor 10; FGF-10; Keratinocyte growth factor 2; FGF10; KGF-2; KGF2
Species	Human
Expression System	E. coli
Mol. Weight	19.3kDa
Expression Region	Gln38-Ser208
Tag Info	Tag free
Formulation	Lyophilized
Buffer	PBS, 5% Mannitol and 0.01% Tween 80, pH7.4.
Size	10μg/50μg/1mg
Lead Time	Products are in stock, but custom products may require further consultation.
Reconstitution	It is recommended to redissolve in sterile deionized water.
Shipping	The product is shipped with blue ice.
Storage & Stability	36 months at -20°C to -80°C in lyophilized state;6 months at -20°C to -80°C under sterile conditions after reconstitution;7-10 days at 2°C to 8°C under sterile conditions after reconstitution;Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Features

✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results.
✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches.
✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements.

Applications

Stem Cell Research

Enhances proliferation and differentiation of epithelial stem cells and organoids.

Cell Biology

Key regulator of epithelial morphogenesis and tissue regeneration.

Data Figures

Instructions for Use

Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
Do not mix with other similar products to avoid cross-reactivity and potential interference.

Cautions

• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.

• Preservation: Handle according to instructions to preserve its activity and stability.

• Support: Contact our technical support team if you encounter any issues or questions.

Documents

📄 Download COA

Recombinant Human FGF-10