{"product_id":"recombinant-human-ccl4-mip-1β-protein","title":"Recombinant Human CCL4\/MIP-1β Protein","description":"\u003cp\u003e\u003cstrong\u003eSynonym: \u003c\/strong\u003eACT2; G-26; HC21; LAG1; LAG-1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MIP-1-beta;CCL4\u003c\/p\u003e\n\u003ch2\u003eBackground\u003c\/h2\u003e\n\u003cp\u003eMonokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5-mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.\u003c\/p\u003e\n\u003ch2\u003eDescription\u003cbr\u003e\n\u003c\/h2\u003e\n\u003cp\u003eHigh quality, high purity and low endotoxin recombinant Recombinant Human CCL4\/MIP-1β Protein (RP01654), tested reactivity in HEK293 cells and has been validated in SDS-PAGE.100% guaranteed.\u003c\/p\u003e\n\u003ch2\u003eSpecification\u003c\/h2\u003e\n\u003ctable border=\"1\" style=\"border-collapse: collapse; width: 90%; height: 198px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 22px;\"\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003e\u003cstrong\u003eSpecies\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003eHuman\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 22px;\"\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003e\u003cstrong\u003eGene ID\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003e\u003ca href=\"http:\/\/www.ncbi.nlm.nih.gov\/entrez\/query.fcgi?db=gene\u0026amp;cmd=Retrieve\u0026amp;dopt=Graphics\u0026amp;list_uids=6351\"\u003e6351\u003c\/a\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 22px;\"\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003e\u003cstrong\u003eExpressed Host\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003eHEK293 cells\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 22px;\"\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003e\u003cstrong\u003eCalculated MW\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003e33.78 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 22px;\"\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003e\u003cstrong\u003eObserved MW\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003e40 kDa\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 22px;\"\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003e\u003cstrong\u003eTag\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003eC-hFc\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 22px;\"\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003e\u003cstrong\u003ePurity\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003e≥ 95 % as determined by SDS-PAGE.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 22px;\"\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003e\u003cstrong\u003eEndotoxin\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003e\u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 22px;\"\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003e\u003cstrong\u003eFormulation\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 50%; text-align: center; height: 22px;\"\u003eLyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch2\u003eReconstitution\u003c\/h2\u003e\n\u003cp\u003eCentrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg\/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.\u003c\/p\u003e\n\u003ch2\u003eStorage\u003c\/h2\u003e\n\u003cp\u003eStore at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.\u003c\/p\u003e\n\u003cp\u003eAfter reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\u003ch2\u003eDocuments\u003c\/h2\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0521\/5312\/2997\/files\/RP01654.pdf?v=1773985005\"\u003e\u003cstrong\u003eData Sheet\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0521\/5312\/2997\/files\/SDS_ABclonal_recombinant_protein_No_hazards.pdf?v=1773985005\"\u003e\u003cstrong\u003eSDS\u003c\/strong\u003e\u003c\/a\u003e\u003c\/p\u003e","brand":"abclonal","offers":[{"title":"10μg","offer_id":52368760668341,"sku":"RP01654-10μg","price":116.0,"currency_code":"USD","in_stock":true},{"title":"20μg","offer_id":52368760701109,"sku":"RP01654-20μg","price":189.0,"currency_code":"USD","in_stock":true},{"title":"50μg","offer_id":52368760733877,"sku":"RP01654-50μg","price":290.0,"currency_code":"USD","in_stock":true},{"title":"100μg","offer_id":52368760766645,"sku":"RP01654-100μg","price":435.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0521\/5312\/2997\/files\/1_72238905-135d-4f7d-97bd-f61251059190.jpg?v=1773976891","url":"https:\/\/biofargo.com\/products\/recombinant-human-ccl4-mip-1%ce%b2-protein","provider":"Biofargo","version":"1.0","type":"link"}