Description

CD16 monoclonal antibody targets T cells， NK cells, macrophages, and neutrophils. By cross-linking CD16, it enhances the antibody-dependent cellular cytotoxicity (ADCC) of NK cells and activates their function. Additionally, it mediates phagocytosis, promoting the engulfment of antibody-coated target cells (such as tumor cells) by macrophages and neutrophils. Downstream applications are widely seen in tumor immunotherapy—for example, bispecific antibodies engaging CD16 to enhance NK cell killing—as well as in infectious disease research.

Specifications

Product Details
Cat. No.	C02402
Purity	≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining).
Endotoxin	≤1 EU/mg by the LAL method.
Bioactivity	≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining).
Species	Mouse
Expression System	CHO
Mol. Weight	150 kDa
Tag Info	Tag free
Formulation	Liquid
Buffer	0.22 μm-filtered solution containing PBS, 0.01%Tween 80 pH 7.4.
Size	500μg/1mg
Lead Time	Products are in stock, but custom products may require further consultation.
Shipping	The product is shipped with blue ice.
Storage & Stability	24 months at -20°C to -80°C under sterile conditions;6 months at 2°C to 8°C under sterile conditions;Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Features

✔ High Purity: This product undergoes stringent purification processes, achieving a purity level of over 95%,ensuring the reliability and reproducibility of experimental results.
✔ High Biological Activity: Verified through multiple activity assays, this product effectively induces the expectedbiological responses in target cells.
✔ Batch Consistency: Manufactured under strict production and quality control protocols to ensure highconsistency between batches.
✔ Animal-Free: Produced without the use of animal-derived components, meeting animal-free requirements.

Applications

Immunology

Fc receptor on NK cells and myeloid cells, mediates cytotoxicity.

Stem Cell Research

Used to identify/activate NK cells from stem cells.

Cell Biology

Regulates antibody-dependent cellular cytotoxicity (ADCC).

Data Figures

Instructions for Use

Dissolve the lyophilized powder in an appropriate sterile buffer in a sterile environment before use.
Prepare and dilute the solution according to experimental requirements to ensure accurate and reproducible results.
Do not mix with other similar products to avoid cross-reactivity and potential interference.

Cautions

• Research Use Only: This product is not suitable for clinical diagnostics or therapeutic applications.

• Preservation: Handle according to instructions to preserve its activity and stability.

• Support: Contact our technical support team if you encounter any issues or questions.

Documents

📄 Download COA

Recombinant Anti-Human CD16 mAb