Description

Rapamycin was used as a kind of original antifungal antibiotic, which is produced by Streptomyces hygroscopicus. Now it has been used in the prevention of transplant rejection because of its immunosuppressive effect. It also exhibits activity against several transplantable tumors and slightly activity to inactive against leukemias. The immunosuppressive effect of Rapamycin is exerted by inhibiting the activation and proliferation of T cells. Rapamycin binds to FK-binding protein 12 (FKBP12) and forms the rapamycin-FKBP12 complex, which regulates an enzyme that plays an important role in the progression of the cell cycle.

Specifications

Item	Value
Chemical Name	Rapamycin
CAS No.	53123-88-9
Molecular Formula	C51H79NO13
Molecular Weight	914.17
Purity	≥99%
IC50 and Target	0.1 nM in HEK 293 Cells
Solubility	DMSO: 50 mg/ml DMSO: 125 mg/ml (136.74 mM, with Ultrasonic) Ethanol: 50 mg/ml

Features

High Purity (≥99%)

Ensures reliable and reproducible results in sensitive biochemical and cellular assays.
Potent mTOR Pathway Inhibitor

Forms a complex with FKBP12 to regulate key enzymes involved in cell cycle progression.
Well-Characterized Biological Activity

Demonstrates strong inhibitory activity in cellular models, including HEK 293 cells.
Excellent Solubility

Readily soluble in DMSO and ethanol for convenient preparation of stock solutions.
Research-Grade Quality

Suitable for advanced studies in immunology, oncology, and signal transduction.

Applications

mTOR signaling pathway research
Immunology and T-cell activation studies
Cancer and tumor biology research
Cell cycle and proliferation analysis
Mechanistic studies in molecular and cellular biology

Documents

MSDS

COA

Data Sheet

Rapamycin 99%