Specification

Full name	PRKCZ (phospho-Thr410/Thr412) rabbit monoclonal antibody
Alternative names	50 μl/100 μl
Reactivity	rabbit monoclonal
Applications	WB, IHC
Host	Rabbit
Clone type	rabbit monoclonal
Target Background	Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
Swissprot No	Q05513
Gene Accession	5590
WB Predicted band size
WB Positive control	P291230-WB-1-P
WB Recommended dilution	78 kDa
IHC predicted cell location	Predicted cell location: Cytoplasm
IHC positive control	Positive control: Human Brain
IHC Recommed dilution	Recommended dilution: 50-100

Storage

-20°C, 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA. Avoid repeated freeze-thaw cycles.

P291230-WB-1-P

Immunohistochemical analysis of paraffin-embedded Human Brain tissue using P291230(PRKCZ (phospho-Thr410/Thr412) Antibody) at dilution 1/50