Description

Pexidartinib (PLX-3397) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib (PLX-3397) exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib (PLX-3397) induces cell apoptosis and has anti-tumor activity.

For research use only. We do not sell to patients.

Specification

CAS No.	1029044-16-3
Synonyms	PLX3397
Molecular Formula	C₂₀H₁₅ClF₃N₅
Formula Weight	417.81
Purity	≥98%
Formulation	A crystalline solid
Solubility	DMF: 20 mg/ml DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml DMSO: 20 mg/ml
Color	Off-white to light yellow
SMILES	ClC1=CC2=C(N=C1)NC=C2CC3=CN=C(NCC4=CN=C(C(F)(F)F)C=C4)C=C3
InChi Code	InChI=1S/C20H15ClF3N5/c21-15-6-16-14(10-28-19(16)29-11-15)5-12-2-4-18(26-7-12)27-9-13-1-3-17(25-8-13)20(22,23)24/h1-4,6-8,10-11H,5,9H2,(H,26,27)(H,28,29)
InChi Key	JGWRKYUXBBNENE-UHFFFAOYSA-N

Pexidartinib (PLX3397)