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Neomycin sulfate from Yeasen is supplied in the form of white powder and is a USP-grade reagent with a solubility of about 200 mg/mL in water. It is an aminoglycoside antibiotic and can inhibit DNA degradation induced by DNase I.
Neomycin sulfate, an aminoglycoside antibiotic, exerts antibacterial activity through irreversible binding of the nuclear 30S and 50S ribosomal subunit, thereby blocking bacterial protein synthesis. Neomycin sulfate inhibits PLC (Phospholipase C) via binding to inositol phospholipids. It also inhibits phosphatidylcholine-PLD activity and induces Ca2+ mobilization and PLA2 activation in human platelets. Neomycin sulfate inhibits DNA degradation induced by DNase I.
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