Description

YamayBio Mariculture SHC is a purified shrimp (Penaeus vannamei) hemocyanin. It can serve as a substitute for Keyhole Limpet Hemocyanin (KLH) as a carrier protein for conjugation with low molecular weight molecules such as peptides, nucleic acids, drugs, or toxins, imparting high immunogenicity to them. Testing has shown that SHC exhibits comparable immunogenicity to KLH, while its solubility (especially after conjugation with haptens) is significantly higher than that of KLH, providing greater flexibility in immunogen preparation protocols.

Specification

Product Type	Protein
Form	Dark Blue Powder
Quantity	10 mg / 100 mg / 600 mg
Purity (MPLC-SEC)	≥ 98%
Molecular Weight	70 KD and 73 KD
Extinction Coefficient	280 nm (ε = 1.277 cm⁻¹ × mg¹ × mL)

Features

High-yield Conjugation

One molecule of SHC contains greater than 20 primary amines available for coupling haptens via EDC or NHS ester crosslinkers.
Validated Quality

Purified and stabilized mariculture SHC maintains solubility in aqueous solutions, unlike traditional carrier protein sources.
Sustainable Source

SHC is harvested from select populations of Penaeus Vannamei grown in mariculture, not extracted from wild populations.
Highly Immunogenic

SHC forms polymers in PBS buffer and elicits a strong immune response equivalent to KLH.
Highly Soluble

The solubility of SHC-peptide conjugates is higher than that of KLH-peptide conjugates
Straightforward Conjugation

Directly mix the hapten containing a free thiol group with the SMCC-activated SHC to prepare hapten antigens.

Documents

COA

SDS

User Guide

Native SHC Protein (Shrimp Hemocyanin, SMCC-Activated, KLH substitution)-Yamaybio