Specifications

Grade	Ultra Pure
Formula	C₂₀H₃₈N₆O₄•0.5H₂SO₄
MW	426.55 • 49.04
CAS	103476-89-7
Appearance	White amorphous powder
Optical rotation (2%, water) [α] ²⁰D	Report IR spectrum conforms to reference spectrum
Storage	-20℃. Keep dry. Warm to room temperature before opening

Biochem/physiol Actions

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Documents

COA

SDS

Leupeptin (Acetyl-Leu-Leu-Arginal)