Description

Hygromycin B is an aminoglycosidic antibiotic purified from Streptomyces hygroscopicus. It acts by binding to the 70S subunit of the bacterial ribosome and inhibiting protein synthesis, leading to the death of bacteria, fungi and mammalian cells.

Resistance to Hygromycin B is conferred by the E. coli hygromycin resistance gene (hyg or hph). Therefore, Hygromycin B can be used to select and maintain prokaryotic and eukaryotic cells transfected with the hygromycin resistance gene. Low purity hygromycin can cause different toxic effects, so it is crucial to grasp its purity in the experiment.

Specifications

Refrigeration Requirements	Refrigerator
Shipping Conditions	ICE
UNSPSC Code	51101500
UNSPSC Category	Antibiotics and Antimycotics
Hazard Class	Class 6.1
Hazard UN	UN3462
Grade	PGI
CAS	[31282-04-9]
DG	No
Storage	2 to 8℃
Sterile	Yes

Application

Hygromycin B is an aminoglycosidic antibiotic that inhibits protein synthesis in prokaryotes and eukaryotes. It is used to select and maintain the phenotype of eukaryotic cells that are stably transfected with the E. coli hygromycin-resistance gene (hyg or hph).

Biochem/physiol Actions

Mode of Action: The product acts by inhibiting protein synthesis by inducing the misreading of the m-RNA template in the prokaryote, with the potency to inhibit translation.

Antimicrobial Spectrum: Hygromycin B acts against bacteria, fungi and higher eukaryotic cells.

Storage

Store at 2 to 8 °C. (solution)

Documents

COA

SDS

Disclaimer: For laboratory research use only.