Bcakground

TGF-beta 2 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF-beta superfamily that share a characteristic cystine knot structure . TGF-beta 1, -2 and -3 are highly pleiotropic cytokines that are proposed to act as cellular switches that regulate processes such as immune function, proliferation and epithelial-mesenchymal transition . Each TGF-beta isoform has some non‑redundant functions; the TGFB2 gene, which encodes transforming growth factor β2 (TGFβ2), making it an obvious candidate gene for this aneurysm phenotype with MFS- and LDS-like features.Human TGF‑ beta 2 cDNA encodes a 414 amino acid (aa) precursor that contains a 20 aa signal peptide and a 394 aa proprotein . A furin‑like convertase processes the proprotein to generate an N‑terminal 282 aa latency‑associated peptide (LAP) and a C‑terminal 112 aa mature TGF‑ beta 2 (1-5).

Specifications

Synonyms	BSC-1 cell growth inhibitor; cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; MGC116892; polyergin; TGFB2; TGFbeta 2; TGF-beta 2; TGF-beta2; TGF-beta-2; transforming growth factor beta-2; transforming growth factor, beta 2
Accession #	P61812
Source	HEK293
Source	Ala303-Ser414
Predicted Moleucular weight	12.7 kDa (monomer)

Components and Storage

Formulation	Solution protein
	Dissolved in sterile 20 mM sodium citrate(pH=2.5) buffer .
	This solution can be diluted into other aqueous buffers. Centrifuge the vial prior to opening.
Storage and Stability	Avoid repeated freeze-thaw cycles.
	It is recommended that the protein be aliquoted for optimal storage.
	12 months from date of receipt, -20 to -70℃ as supplied
Shipping	Shipping with dry ice

Quality

Purity	> 95%, determined by SDS-PAGE.
Endotoxin Level	＜0.10 EU per 1 ug of the protein by the LAL method
Activity	Measured by the(CAGA)₁₂-luciferase reporter assay
Activity	The EC50 for this effect is 0.69ng/mL

SDS-PAGE

Bioactivity

Documents

Human TGFb2