Description

GSK 126 is a very high affinity and selective EZH2 inhibitor (Ki = 0.5 - 3 nM). Exhibits >150-fold selectivity for EZH2 over EZH1 and >1000-fold selectivity over 20 other human methyltransferases. Inhibits proliferation of B-cell lymphoma cell lines in vitro. Also inhibits H3K27Me3 and tumor growth in mice bearing BCL xenografts. Targeting p53 and histone methyltransferases restores exhausted CD8+ T cells in HCV infection. Promotes the transition of ESCs to feeder-free extended pluripotent stem (EPS) cells in combination with LCDM cocktail.

For research use only. We do not sell to patients.

Specification

Chemical Name	N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide
M. Wt	526.67
Formula	3.47594%;">C₃₁H₃₈N₆O₂
Storage	Store at -20°C
Purity	≥98%
CAS No.	1346574-57-9
PubChem ID	68210102
InChI Key	FKSFKBQGSFSOSM-QFIPXVFZSA-N
SMILES	CC1=CN([C@@H](C)CC)C2=CC(C(C=C3)=CN=C3N4CCNCC4)=CC(C(NCC5=C(C)C=C(C)NC5=O)=O)=C21

GSK126 (CAS 1346574-57-9)