Specification

Full name	GREM1 rabbit polyclonal antibody
Alternative names	50 μl/100 μl
Reactivity	rabbit polyclonal
Applications	WB
Host	Rabbit
Clone type	rabbit polyclonal
Target Background	This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Swissprot No	O60565
Gene Accession	BC069525
WB Predicted band size
WB Positive control	P100267-WB-1-P
WB Recommended dilution	21 kDa
IHC predicted cell location
IHC positive control
IHC Recommed dilution

Storage

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

P100267-WB-1-P