Product Profile

Product Name	CX3CR1 Antibody
Antibody Type	Primary Antibodies
Product description	CX3CR1 Antibody: CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, murine, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration and adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.1) Raport CJ, Schweickart VL, Eddy RL JR, Shows TB, Gray PW. The orphan G-protein-coupled receptor-encoding gene V28 is closely related to genes for chemokine receptors and is expressed in lymphoid and neural tissues. Gene 1995;163:295-9
Immunogen	CX3CR1 antibody was raised against a 20 amino acid peptide near the amino terminus of human CX3CR1. The immunogen is located within the first 50 amino acids of CX3CR1.

Key Feature

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Applications	ELISAFACSIFIHC-PWB
	CX3CR1 antibody can be used for detection of CX3CR1 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 10 μg/mL. Flow cytometry at 0.1 μg/ml.:
Species Reactivity	HumanMouseRat
Concentration	1 mg/ml
Purification	Affinity purified

Target Information

Gene Symbol	CX3CR1
Alternative Names	CX3CR1 Antibody: V28 CCRL1 GPR13 CMKDR1 GPRV28 CMKBRL1 CX3C chemokine receptor 1 Beta chemokine receptor-like 1 C-X3-C CKR-1
Molecular Weight(MW)	50 kDa
Sequence Similarities	2) Cat. No. 10-501 - Human Heart Tissue Slide

Database Links

Entrez Gene	1524
Protein Accession	NP_001328

Application

Positive Control: 1) Cat. No. 1306 - Human Spleen Tissue Lysate

Application Notes : CX3CR1 antibody can be used for detection of CX3CR1 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2 μg/mL. For immunofluorescence start at 10 μg/mL. Flow cytometry at 0.1 μg/ml.:

Additional Information

Form	Liquid
Storage Instructions	CX3CR1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage Buffer	CX3CR1 Antibody is supplied in PBS containing 0.02% sodium azide.

Note: The product is for research use only,not for use in diagnostic or therapeutic procedures.

CX3CR1 Antibody