Description

Actinomycin D is a polypeptide antibiotic first described by Waksman. It is bacteriostatic in nature, especially towards gram negative bacteria, and also has anti-tumor activity.

Chemical structure: peptide

Specifications

Total Product Size	5mg
Individual Container Size	5mg
Refrigeration Requirements	Refrigerator
Shipping Conditions	ICE
UNSPSC Code	51101500
UNSPSC Category	Antibiotics and Antimycotics
CAS	[50-76-0]
Hazard Class	Class 6.1
Hazard UN	UN3462
Hazard PG	PGII
Grade	Ultra Pure
DG	No
Storage	2 to 8℃
Sterile	Yes

Application

Actinomycin D has a wide-ranging applications ranging from a selection agent in cell culture, use in studies of suppressing HIV-replication and programmed cell death of PC12 cells.

Biochem/physiol Actions

Actinomycin D inhibits the proliferation of cells by forming a stable complex with double-stranded DNA, inhibiting DNA-primed RNA synthesis and causing single-stranded breaks in DNA. It has been shown to be an inhibitor of the minus-strand transfer step in reverse transcriptase.

Note

This product is hygroscopic and light-sensitive. If stored protected from light and moisture at 2-8°C, it remains unchanged, by HPLC testing, for at least 15 months. Unused dilute solutions of Actinomycin D are extremely sensitive to light and tend to adsorb to plastic and glass and should be discarded. However, frozen aliquots of concentrated stock solution are stable for at least a month.

Documents

COA

SDS

Disclaimer: For laboratory research use only.