Acetylcholine Chloride

Description

Acetylcholine is a neurotransmitter released at nerve endings in both the central and peripheral nervous systems.[1] Acetylcholine chloride (C7H16ClNO2) is a stable cholinergic agonist with muscarinic and nicotinic actions.[2] It is available as white or off-white hygroscopic crystals, or as a crystalline powder. Acetylcholine chloride is hygroscopic in nature and is highly soluble in water, alcohol, propylene glycol and chloroform.

Specifications

Application

Acetylcholine chloride has been used:

• as an agent to trigger sudomotor axon reflex response during autonomic test

• to induce contraction amplitude of pyloric circular smooth muscle strip (PCSMS) in rats

• as a substrate for acetylcholinesterase

• to stimulate after discharge in Aplysia bag cell neurons

Biochem/physiol Actions

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.

Caution

Very hygroscopic

Documents

COA

MSDS