{"title":"Cancer Immunotherapy","description":"","products":[{"product_id":"human-pdl1","title":"Human PDL1","description":"PDL1 is one of the ligands for PD-1 and plays a critical role in the regulation of T cell immunity. Mature human PDL1 protein is is expressed on inflammatory-activated immune cells including macrophages, T cells, and B cells, keratinocytes, endothelial and intestinal epithelial cells, as well as a variety of carcinomas and melanoma. The PD-1:PD-L1 interaction initiates a negative signaling cascade in T cells leading to inhibition of T cell activation. Many cancers exhibit upregulated PD-L1 protein expression, and several cancers with high levels of PD-L1 have been associated with increased tumor aggressiveness and poor prognosis. Using new therapeutics that block the PD-L1:PD-1 interaction has proven successful in the clinic for many cancer types and has sparked great interest in the field of cancer immunotherapy （1-5）.","brand":"Bostonmolecules","offers":[{"title":"10ug","offer_id":51241403809973,"sku":"RP457-10UG","price":85.0,"currency_code":"USD","in_stock":true},{"title":"50ug","offer_id":51241403842741,"sku":"RP457-50UG","price":155.0,"currency_code":"USD","in_stock":true},{"title":"1mg","offer_id":51241403875509,"sku":"RP457-1MG","price":1010.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0521\/5312\/2997\/files\/HumanIL1a_86e3f2c7-e9bd-4dc8-b510-832aea29fce4.jpg?v=1750429569"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0521\/5312\/2997\/collections\/00002_9b27b73b-ea79-47eb-9bc9-cf359a960eb0.jpg?v=1776236864","url":"https:\/\/biofargo.com\/collections\/cancer-immunotherapy.oembed","provider":"Biofargo","version":"1.0","type":"link"}